TRK-A is the high affinity catalytic receptor for the neurotrophin Nerve Growth Factor. Besides mediating neuronal differentiation and survival, it plays a role in the tumorigenesis of non neural tumors, primarily carcinomas.

PRODUCT

1. Each vial contains the indicated amount of IgG (caprylic acid purified) in 0.1% gelatine and 0.05% NaN3.

2. Unpurified reagent is provided at the indicated amounts with 0.1% NaN3.

Centrifuge the vial prior to use.

SPECIFICITY

The murine monoclonal antibody MP-AA-6 (IgG-2a), has been generated using as immunogen NIH-3T3 cells transfected with the full length human molecule. It recognizes the receptor with an affinity of 2×10- 11 M.

STORAGE

Store frozen, avoid repeated freezing-thawing. Stable for 2 yrs.

SHIPPING CONDITIONS

Room temperature.

RESEARCH USE

This antibody is for laboratory research use only, not for human or in-vivo use.

APPLICATIONS

Flow Cytometry, 5-10 µg/ml.

Immunohistochemistry (fluourescence, enzymatic), Acetone fixed cryostat sections or cytospins (20 µg/ml).

Immunoprecipitation, 5-10 µg, using rabbit anti-mouse Ig and protein ASepharose.

REFERENCES
1. Eur J Cancer (1995) 31: 44.
2. J Neurooncol (1997) 31: 57.