Integrins are cell surface receptors mediating cell to cell and cell to extracellular matrix (ECM) interactions. They exist as non covalently linked alfa and beta subunits heterodimers displaying specificity for one or more ligands.

PRODUCT
1. Each vial contains the indicated amount of of IgG (caprylic acid purified) in 0.1% gelatine and 0.05% NaN3.
1. Unpurified reagent is provided at the indicated amounts with 0.1% NaN3.
Centrifuge the vial prior to use.

SPECIFICITY
The murine monoclonal antibody MP-AA-3 (IgG1k ) has been generated using as immunogen the renal carcinoma cell line KJ29(1). It recognizes an epitope shared by the α3/β1 heterodimer (IHC World Image Gallery), the receptor for Laminin, the major component of basement membranes (2-5). By mediating TGF- β1 signalling, α3/β1 integrin leads to epithelial mesenchymal transition (6).

STORAGE
Store frozen, avoid repeated freezing-thawing. Stable for 2 yrs.

SHIPPING CONDITIONS
Room temperature.

RESEARCH USE
This antibody is for laboratory research use only, not for human or in-vivo use.

REFERENCES
1. Hybridoma(1991) 10: 707
2. Pathol Res Pract (1993) 189: 387
3. Int J Cancer (1993) 54: 68
4. Int J Cancer (1994) 58: 488
5. Int J Cancer (2000) 87: 336
6. J Cell Biol (2009) 184: 309
7. NEJM (2012) 366: 1508