BACKGROUND
CD56 (NCAM) is a cell surface glycoprotein which occurs in numerous isoforms which mediated homophylic cell interactions. The insertion of other exons in the NCAM transcript increases the complexity and the spectrum of activities of these glycoproteins. It induces neurite outgrowth via the Fibroblast Growth Factor receptor.

PRODUCT
Each vial contains the indicated amount of IgG (HPLC, Prot. A) in 0,1% gelatine and 0,05% NaN3.

SUBCLASS
Mouse IgG1.

SPECIFICITY
Known also as: Leu-19; NKH1; NCAM is expressed on: NK cells , non-MHC restricted T-cell,
cerebellum, cortex, neuromuscolar junctions and in the following malignancies: myeloma, myeloid leukemia,
NK T cell lymphomas, neuroendocrine tumors, paraganglioma adult neuroblastoma,
melanoma, small cell lung carcinoma, Ewing sarcoma. CD56 immunotherapy has been attempted in
neuroblastoma, small cell lung cancer.

STORAGE
Store frozen, avoid repeated freeze-thawing. Stable for 2 yrs.

SHIPPING CONDITIONS
Room temperature.

RESEARCH USE
This antibody is for laboratory research use only, not for human or in-vivo use.

APPLICATIONS
See enlisted references.

REFERENCES
J Biol Regul Homeost Agents (2002) 16: 173.