Anti-Gal-3BP Antibody

MP-1959 is the humanized version of the murine monoclonal antibody SP-2 which was originally raised against human Gal-3 BP (also known as LGALS3BP, 90K or Mac-2 BP), a glycoprotein secreted in large amounts by the majority of cancer cells. Functionally, Gal-3BP plays an important role in cell-cell and cell-extracellular matrix adhesion, angiogenesis, tumor progression and metastasis.

MP-1959, given alone or in combination with other biological agents has shown significant therapeutic activity in several xenograft models, including breast cancer (triple negative), ovarian cancer, prostate cancer and head & neck cancer.